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KMID : 0364519950070010029
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Dong-A Journal Medicine
1995 Volume.7 No. 1 p.29 ~ p.36
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An Immunohistochemical Study of p53 Protein Expression Pattern in Uterine Cervical Carcinoma
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Abstract
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A study on the incidence and pattern of mutant p53 protein was done in 73 cases of uterine cervical squamous cell carcinomas by immunohistochemical method. The incidence of mutant p53 protein was 27.4% (20 of 73 cases) and the expression pattern
was
variable from weak to strong intensity in small numbers of tumor cells. There was no significant correlation between the incidence of p53 protein expression and patient age and depth of invasion and histological type of the tumor.
However, the incidence of p53 protein expression in cervical carcinoma of Korean women in this study was relatively higher than previous reports studied in western countries, and this result suggests that inactivation of wild-type p53 protein by
mutant
p53 protein as well as loss of wild-type p53 function by binding with HPV E6 viral oncoprotein in HPV-positive cancer were associated with pathogenesis of uterine cervical carcinoma. It is supposed that the transformed cells then have increase
risk
of
additional genetic defect and they can progress to more aggressive carcinoma by activation oncogenes together with inactivation of p53 protein. Genetic analysis in tumor cells is required to confirm the hypothesis that mutation of p53
tumor-suppressor
gene plays an important role in development and progression of uterine cervical carcinoma in korean women.
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